The INTS2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to INTS2. This antibody recognizes Human, and Mouse antigen. The INTS2 Antibody has been validated for the following applications: ELISA, Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
Function: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).
Subunit Structure: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
Similarity: Belongs to the Integrator subunit 2 family